CovidV1, Main, Exploration, bibRecord, 000A29

Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens.

Identifieur interne : 000A29 ( Main/Exploration ); précédent : 000A28; suivant : 000A30

Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens.

Auteurs : Amber Marie Kameka [Canada] ; Siamak Haddadi [Canada] ; Dae Sun Kim [Canada] ; Susan Catherine Cork [Canada] ; Mohammad Faizal Abdul-Careem [Canada]

Source :

Virology [ 1096-0341 ] ; 2014.

RBID : pubmed:24503073

Descripteurs français

English descriptors

KwdEn :
- Animals, Avian Proteins (genetics), Avian Proteins (immunology), Chickens, Coronavirus Infections (genetics), Coronavirus Infections (immunology), Coronavirus Infections (veterinary), Coronavirus Infections (virology), Immunity, Innate, Infectious bronchitis virus (immunology), Infectious bronchitis virus (physiology), Poultry Diseases (genetics), Poultry Diseases (immunology), Poultry Diseases (virology), Respiratory System (immunology), Respiratory System (virology), Toll-Like Receptor 3 (genetics), Toll-Like Receptor 3 (immunology), Toll-Like Receptor 7 (genetics), Toll-Like Receptor 7 (immunology).
MESH :
- chemical , genetics : Avian Proteins, Toll-Like Receptor 3, Toll-Like Receptor 7.
- chemical , immunology : Avian Proteins, Toll-Like Receptor 3, Toll-Like Receptor 7.
- genetics : Coronavirus Infections, Poultry Diseases.
- immunology : Coronavirus Infections, Infectious bronchitis virus, Poultry Diseases, Respiratory System.
- physiology : Infectious bronchitis virus.
- veterinary : Coronavirus Infections.
- virology : Coronavirus Infections, Poultry Diseases, Respiratory System.
- Animals, Chickens, Immunity, Innate.

Abstract

Infectious bronchitis virus (IBV) replicates in the epithelial cells of trachea and lungs of chicken, however the mechanism of generation of innate immune response against IBV infection in these tissues has not been fully characterized. Our objective was to study innate responses induced early following IBV infection in chickens. Initiation of the transcription of selected innate immune genes such as TLR3, TLR7, MyD88, IL-1β and IFN-β, as well as recruitment of macrophages, were evident following an initial down regulation of some of the observed genes (TLR3, IL-1β, and IFN-γ) in trachea and lung. This initial down-regulation followed by the induction of innate immune response to IBV infection appears to be inadequate for the control of IBV genome accumulation and consequent histopathological changes in these tissues. Potential induction of innate immunity before infection occurs may be necessary to reduce the consequences since vaccine induced immunity is slow to develop.

DOI: 10.1016/j.virol.2013.12.001
PubMed: 24503073

Affiliations:

Le document en format XML

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<term>Avian Proteins (immunology)</term>
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<term>Coronavirus Infections (genetics)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (veterinary)</term>
<term>Coronavirus Infections (virology)</term>
<term>Immunity, Innate</term>
<term>Infectious bronchitis virus (immunology)</term>
<term>Infectious bronchitis virus (physiology)</term>
<term>Poultry Diseases (genetics)</term>
<term>Poultry Diseases (immunology)</term>
<term>Poultry Diseases (virology)</term>
<term>Respiratory System (immunology)</term>
<term>Respiratory System (virology)</term>
<term>Toll-Like Receptor 3 (genetics)</term>
<term>Toll-Like Receptor 3 (immunology)</term>
<term>Toll-Like Receptor 7 (genetics)</term>
<term>Toll-Like Receptor 7 (immunology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Appareil respiratoire (immunologie)</term>
<term>Appareil respiratoire (virologie)</term>
<term>Immunité innée</term>
<term>Infections à coronavirus (génétique)</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (médecine vétérinaire)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Maladies de la volaille (génétique)</term>
<term>Maladies de la volaille (immunologie)</term>
<term>Maladies de la volaille (virologie)</term>
<term>Poulets</term>
<term>Protéines aviaires (génétique)</term>
<term>Protéines aviaires (immunologie)</term>
<term>Récepteur de type Toll-3 (génétique)</term>
<term>Récepteur de type Toll-3 (immunologie)</term>
<term>Récepteur de type Toll-7 (génétique)</term>
<term>Récepteur de type Toll-7 (immunologie)</term>
<term>Virus de la bronchite infectieuse (immunologie)</term>
<term>Virus de la bronchite infectieuse (physiologie)</term>
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<term>Toll-Like Receptor 3</term>
<term>Toll-Like Receptor 7</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Avian Proteins</term>
<term>Toll-Like Receptor 3</term>
<term>Toll-Like Receptor 7</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus Infections</term>
<term>Poultry Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Maladies de la volaille</term>
<term>Protéines aviaires</term>
<term>Récepteur de type Toll-3</term>
<term>Récepteur de type Toll-7</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Appareil respiratoire</term>
<term>Infections à coronavirus</term>
<term>Maladies de la volaille</term>
<term>Protéines aviaires</term>
<term>Récepteur de type Toll-3</term>
<term>Récepteur de type Toll-7</term>
<term>Virus de la bronchite infectieuse</term>
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<term>Infectious bronchitis virus</term>
<term>Poultry Diseases</term>
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<term>Maladies de la volaille</term>
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<front><div type="abstract" xml:lang="en">Infectious bronchitis virus (IBV) replicates in the epithelial cells of trachea and lungs of chicken, however the mechanism of generation of innate immune response against IBV infection in these tissues has not been fully characterized. Our objective was to study innate responses induced early following IBV infection in chickens. Initiation of the transcription of selected innate immune genes such as TLR3, TLR7, MyD88, IL-1β and IFN-β, as well as recruitment of macrophages, were evident following an initial down regulation of some of the observed genes (TLR3, IL-1β, and IFN-γ) in trachea and lung. This initial down-regulation followed by the induction of innate immune response to IBV infection appears to be inadequate for the control of IBV genome accumulation and consequent histopathological changes in these tissues. Potential induction of innate immunity before infection occurs may be necessary to reduce the consequences since vaccine induced immunity is slow to develop.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
<region><li>Alberta</li>
</region>
<settlement><li>Calgary</li>
</settlement>
<orgName><li>Université de Calgary</li>
</orgName>
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<tree><country name="Canada"><region name="Alberta"><name sortKey="Kameka, Amber Marie" sort="Kameka, Amber Marie" uniqKey="Kameka A" first="Amber Marie" last="Kameka">Amber Marie Kameka</name>
</region>
<name sortKey="Abdul Careem, Mohammad Faizal" sort="Abdul Careem, Mohammad Faizal" uniqKey="Abdul Careem M" first="Mohammad Faizal" last="Abdul-Careem">Mohammad Faizal Abdul-Careem</name>
<name sortKey="Cork, Susan Catherine" sort="Cork, Susan Catherine" uniqKey="Cork S" first="Susan Catherine" last="Cork">Susan Catherine Cork</name>
<name sortKey="Haddadi, Siamak" sort="Haddadi, Siamak" uniqKey="Haddadi S" first="Siamak" last="Haddadi">Siamak Haddadi</name>
<name sortKey="Kim, Dae Sun" sort="Kim, Dae Sun" uniqKey="Kim D" first="Dae Sun" last="Kim">Dae Sun Kim</name>
</country>
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Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens.

Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens.

Source :

Descripteurs français

English descriptors

Abstract

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Le document en format XML

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